ROLE OF THE TRANSCRIPTION FACTOR SOX9 IN THE TUMORIGENESIS OF SOME DOMESTIC ANIMALS NEOPLASMS

    April 2016 in “ Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) ”
    Eleonora Fantinato
    TLDR Sox9 is important in the development of tumors in domestic animals.
    The thesis explored the role of the transcription factor Sox9 in the tumorigenesis of neoplasms in domestic animals. It provided an overview of Sox9's functions in development and diseases, and assessed its immunohistochemical staining in normal tissues of various animal species to validate it as a marker. The research included six original studies on Sox9 expression in different neoplasms, such as canine epithelial skin tumors, canine Sertoli cells, feline mammary hypertrophy and carcinomas, and canine mammary neoplasms. Additionally, Sox9's role in nervous tissue development and neoplastic lesions was examined alongside Sox10, particularly in horse spindle cell tumors.
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