Role of the Wnt/β-Catenin Signaling Pathway in Mediating Outer Root Sheath Stem Cells to Promote Hair Follicle Regeneration and Skin Wound Healing in Mice

This study explores the Wnt/β-catenin signaling pathway's role in hair follicle regeneration and skin wound healing in mice, using 18 suckling mice. Activation of this pathway accelerates the hair follicle cycle and promotes regeneration by enhancing the proliferation and differentiation of hair follicle stem cells, particularly in the outer root sheath. It also aids in skin wound healing by inhibiting adipogenic differentiation and facilitating myofibroblast formation. Inhibition of the pathway reduces stem cell marker expression and delays repair, underscoring its importance. The findings suggest potential therapeutic strategies for hair loss and skin repair, though further research is needed to assess long-term efficacy and applicability in adult models and humans.