S100A4/Nonmuscle Myosin IIA/p53 Axis Contributes to Aggressive Features in Ovarian High-Grade Serous Carcinoma

    August 2020 in “ American Journal Of Pathology ”
    Ai Hiruta, Yasuko Oguri, Ako Yokoi, Toshihide Matsumoto, Yusuke Oda, Mikihisa Tomohiro, Miki Hashimura, Zesong Jiang, Masataka Tochimoto, Mayu Nakagawa, Makoto Saegusa
    TLDR S100A4 promotes aggressive ovarian cancer and is a potential treatment target.
    The study explored the S100A4/Nonmuscle Myosin IIA/p53 axis in ovarian high-grade serous carcinoma (HGSC) and found that S100A4 played a significant role in promoting aggressive cancer features. Knockdown of S100A4 in cell lines led to reduced epithelial-mesenchymal transition, cancer stem cell markers, and cell proliferation, while increasing apoptosis and cell mobility. High S100A4 expression was linked to poor clinical outcomes, serving as an independent unfavorable prognostic factor. The study involved 116 clinical cases and suggested that S100A4, rather than NMIIA or p53, was a key prognostic factor, highlighting its potential as a therapeutic target.
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