Salvianolic acid B ameliorate alopecia by simultaneously targeting Wnt/β-catenin and mTORC2/Akt signaling

    January 2026 in “ Journal of Dermatological Science
    Junjie Cen, Xin Tang, Nan Xu, Yiyong Hong, Tian Liu, Lei Zhou, Zhikai Liao, Miaojian Wan
    The study explores the impact of Salvianolic acid B (Sal B) on hair regeneration, revealing its effectiveness in activating the Wnt/β-catenin and mTORC2/Akt signaling pathways. Sal B binds to the LRP6 receptor, enhancing dermal papilla cell proliferation and hair shaft elongation in vitro. In vivo experiments on mice showed that Sal B surpassed minoxidil in promoting hair regeneration in androgenetic alopecia models. The study emphasizes Sal B's ability to upregulate matrix metalloproteinases (MMPs) and mitogen-activated protein kinases (MAPKs), which are crucial for its hair growth-promoting effects.
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