Angiosarcoma of the Scalp Mimicking an Inflammatory Scarring Alopecia and Diagnosed on Horizontal Histologic Sections

This case report discusses a 72-year-old female patient with angiosarcoma of the scalp, initially misdiagnosed as lichen planopilaris due to its presentation as alopecia with erythematous patches and diffuse hair thinning. Histopathologic examination revealed atypical cells indicative of angiosarcoma, confirmed by immunohistochemistry. The patient responded well to paclitaxel and radiation therapy, although treatment was discontinued due to side effects. Despite recurrence, further treatment led to remission, and the patient survived 5 years post-diagnosis before passing away from unspecified causes. The study highlights the importance of early detection and accurate diagnosis of angiosarcoma, which can mimic inflammatory alopecia, to improve patient outcomes.