Carcinogenesis Of The Human Scalp: An Immunometabolic Centered View

The document explores the role of hair and the underlying stroma in scalp carcinogenesis, noting that hair provides immunological protection against nonmelanoma skin cancers through IL-17 mediated immunosurveillance, although it does not prevent UV-induced mutations. Aging scalps with hair loss and stromal changes become more susceptible to cancer due to decreased Sirt3 levels and increased TGF-beta. The study suggests that sun protection and preventing hair loss could reduce scalp cancer risk. A novel treatment for alopecia, involving a mitochondrial pyruvate transport inhibitor, is being investigated for its potential to promote hair growth and possibly prevent scalp cancer.