Therapeutic Effect of Superficial Scalp Hypothermia on Chemotherapy-Induced Alopecia in Breast Cancer Survivors

Scalp cooling has been identified as the most effective strategy to reduce chemotherapy-induced alopecia (CIA) in breast cancer patients, decreasing the incidence of significant hair loss by 50% and maintaining high patient satisfaction without increasing the risk of scalp metastasis or affecting overall survival. Despite its effectiveness, research on CIA is challenged by heterogeneity and the absence of standardized assessment methods. The article highlights the need for further interdisciplinary research to develop preclinical models, a standardized classification system, and an objective prognosis monitoring system. Emerging technologies like cryogenic nitrogen oxide cryotherapy show promise in enhancing the therapeutic effects of scalp cooling.