Identification and Characterization of Two Se6OMTs from Stephania Epigaea Offer Novel Insights into the Biosynthetic Pathway of Cepharanthine
February 2025
in “
Metabolites
”
TLDR The research found enzymes in Stephania epigaea that help make cepharanthine.
This study identified and characterized Se6OMT enzymes in Stephania epigaea, which are involved in the cepharanthine biosynthetic pathway. The research provides insights into the substrate promiscuity of Se6OMTs on (R)- and (S)-configured 1-BIAs, highlighting the genetic components necessary for metabolic engineering and synthetic biology approaches to cepharanthine production.
