Influence of Sex and Hair Growth Cycle on Lipid Composition of Mouse Epidermis

    February 1962 in “ Experimental Biology and Medicine
    C. Carruthers
    TLDR Male and female mice have different lipid compositions in their skin during hair growth cycles.
    The study examines the lipid composition of mouse epidermis across different stages of the hair growth cycle, highlighting differences between sexes. On the 4th day of the cycle, male epidermis shows lower total lipid content but higher phospholipid levels compared to the 12th and 22nd days. In contrast, female epidermis consistently has twice the total lipid and half the phospholipid content of males at similar stages. Both sexes exhibit a similar pattern in the total lipid-phospholipid ratio throughout the cycle. Additionally, 4th day male epidermis is notable for its high cholesterol content, low triglycerides, and significant lipid material eluted with cholesterol esters.
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