Influence of Sex and Functional Status on the Value of Serum Steroid Profiling in Discriminating Adrenocortical Carcinoma from Adrenocortical Adenoma

    September 2024 in “ Frontiers in Endocrinology
    Yan Weng, Juying Tang, Xiaoyun Zhang, Diaozhu Lin, Ying Guo, Ying Liang, Lin Wang, Jing Zhou, Yan Li, Tian-Xin Lin, Shao‐Ling Zhang
    TLDR Serum steroid profiling, especially 11-deoxycortisol, helps distinguish between adrenocortical carcinoma and adenoma, considering sex and functional status.
    Serum steroid profiling is a useful tool for distinguishing between adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA), with 11-deoxycortisol identified as the most significant marker. The study highlights the importance of considering sex differences and functional status when evaluating other steroid hormones for this purpose.
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