Influence of Sex and Functional Status on the Value of Serum Steroid Profiling in Discriminating Adrenocortical Carcinoma from Adrenocortical Adenoma

September 2024 in “ Frontiers in Endocrinology ”

Yan Weng, Juying Tang, Xiaoyun Zhang, Diaozhu Lin, Ying Guo, Ying Liang, Lin Wang, Jing Zhou, Yan Li, Tian-Xin Lin, Shao‐Ling Zhang

serum steroid profiling adrenocortical carcinoma adrenocortical adenoma 11-deoxycortisol steroid hormones

TLDR Serum steroid profiling, especially 11-deoxycortisol, helps distinguish between adrenocortical carcinoma and adenoma, considering sex and functional status.

Serum steroid profiling is a useful tool for distinguishing between adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA), with 11-deoxycortisol identified as the most significant marker. The study highlights the importance of considering sex differences and functional status when evaluating other steroid hormones for this purpose.

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American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1

research American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1

343 citations , October 2015 in “Endocrine Practice”

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