Levels of Sex Steroids in Lung Tissues of Patients With Non-Small Cell Lung Cancer After COVID-19 of Different Severity

    May 2023 in “ Research and Practical Medicine Journal ”
    Oleg I. Kit, E. M. Frantsiyants, Д. А. Харагезов, В. А. Бандовкина, A. I. Shikhlyarova, N. D. Cheryarina, Yu. A. Pogorelova, Yu. N. Lazutin, А. Г. Милакин, Igor A. Leyman, O. N. Stateshny, T. G. Ayrapetova, I. A. Goroshinskaya
    TLDR Severe COVID-19 may increase lung cancer risk and affect treatment in women due to hormonal changes.
    This study analyzed sex hormone and cortisol levels in lung tissues of 60 patients with stage I–IIIA non-small cell lung cancer (NSCLC) who had previously contracted COVID-19. Patients were divided into two groups based on COVID-19 severity: 30 with severe or moderate cases and 30 with mild or asymptomatic cases. Results showed that severe COVID-19 altered the hormonal profile in lung tissues, particularly in women, with significant increases in estradiol, cortisol, and progesterone, and a decrease in testosterone. These hormonal changes suggest a potential increase in lung cancer incidence, especially in females, and may affect the disease's progression, response to treatment, and complication rates.
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