Simultaneous Estimation of Minoxidil and Tofacitinib Citrate in Bulk and Topical Gel - A Validated UV-spectrophotometric Technique

November 2024 in “ Advances in Pharmacology and Pharmacy ”

Bhuvaneshwari R. Sharannavar, MONALI BHAGAT AMONKAR, A. A. Deo, Shailendra S. Suryawanshi, Nithyanand Sastry Darbha

minoxidil tofacitinib citrate alopecia areata UV-spectrophotometric technique Rogaine

TLDR A reliable method was developed to measure Minoxidil and Tofacitinib in gel for hair loss treatment.

The study successfully developed and validated a UV-spectrophotometric method for the simultaneous estimation of Minoxidil and Tofacitinib citrate in both raw and pharmaceutical forms, specifically in a topical gel for treating Alopecia areata. The method adheres to International Council for Harmonisation guidelines and demonstrates high selectivity, specificity, precision, accuracy, ruggedness, and robustness. Minoxidil and Tofacitinib citrate showed peak absorbance at 258nm and 290nm, respectively, with reliable quantification in the 2-10µg/mL range. The method's detection and quantification limits were established, and recovery rates in gel formulations ranged from 50.00% to 150.00%, confirming its suitability for routine analysis.

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community Topical solution recommendation

in Treatment 2 upvotes 7 months ago

The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

community Topical solution recommendation

in Product 1 upvotes 7 months ago

The user is using finasteride 1mg every other day and seeks a topical solution to complement it, excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

community Finasteride and Oral Minoxidil in Turkey - what I’ve found out

in Finasteride/Dutasteride 11 upvotes 1 year ago

Finasteride is available in Turkey without a prescription, with 1mg tablets costing 800 Turkish lira and 5mg tablets costing 150 lira. Oral minoxidil capsules were found at Cerrahpaşa nur eczanesi, also without a prescription.

community The shedding caused by Minoxidil is one of the worst things. 2 months apart each picture

in Progress Pictures 290 upvotes 1 year ago

The conversation discusses the severe shedding caused by Minoxidil, with users sharing their experiences and outcomes. Some report eventual regrowth, while others see no improvement or worsening hair loss.

community What else is good. Besides the big 3.

in Chat 35 upvotes 1 year ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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