SIRT1-Modified Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Experimental Peritoneal Fibrosis by Inhibiting the TGF-β/Smad3 Pathway

August 2020 in “ Stem Cell Research & Therapy ”

Yanhong Guo, Liuwei Wang, Rong Gou, Yulin Wang, Xiujie Shi, Xinxin Pang, Lin Tang

TLDR SIRT1-modified stem cells can help treat peritoneal fibrosis by blocking a harmful pathway.

The study investigated the therapeutic potential of SIRT1-modified human umbilical cord mesenchymal stem cells (hUCMSCs) for treating peritoneal fibrosis, a complication of long-term peritoneal dialysis. By overexpressing SIRT1, these modified cells showed a stronger anti-fibrosis effect compared to regular hUCMSCs by significantly inhibiting fibrotic gene expression, suppressing the epithelial-mesenchymal transition (EMT) process, increasing ultrafiltration volume, and restoring the balance of bioincompatible factors in dialysis solutions. The mechanism involved reducing peritoneal inflammation and inhibiting the TGF-β/Smad3 pathway. The study involved 8 rats per group and demonstrated that SIRT1-modified hUCMSCs could be a promising therapeutic strategy for peritoneal dialysis-induced peritoneal damage and fibrosis.

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