Research Progress on Mechanisms of Skin Aging and Anti-Aging Strategies
March 2026
in “
Aging Research
”
skin aging anti-aging strategies oxidative stress inflammation collagen degradation UV radiation genetic loci pharmacotherapy natural compounds traditional Chinese medicine physical treatments lifestyle interventions personalized approaches genetic factors epigenetic factors cellular reprogramming gut microbiome regulation sun damage wrinkle treatments herbal remedies Chinese herbs exercise diet customized skincare gene therapy probiotics
The review provides a comprehensive overview of skin aging mechanisms and anti-aging strategies, emphasizing the roles of oxidative stress, inflammation, and collagen degradation, with UV radiation as a major factor. It highlights racial and geographic variations in skin aging and explores diagnostic technologies like imaging and genetic testing. Recent advancements include identifying genetic loci linked to skin aging and promising pharmacotherapy with natural compounds and traditional Chinese medicine. Physical treatments and lifestyle interventions also contribute to anti-aging. The review underscores the importance of personalized approaches, considering genetic and epigenetic factors, and discusses ethical implications and future research directions, such as cellular reprogramming and gut microbiome regulation.
