The Skin and Inflamm-Aging

The review article "The Skin and Inflamm-Aging" explores the concept of "inflamm-aging," which is characterized by chronic low-level systemic inflammation linked to aging. It emphasizes the skin's role as a barrier and its involvement in immune responses, noting that age-related impairments in skin barrier function contribute to systemic inflammation. This inflammation exacerbates age-related conditions and is influenced by factors like UV exposure and oxidative stress. The document highlights molecular mechanisms, such as reduced aquaporin-3 and calcium-sensing receptor levels, which impair skin hydration and repair. Understanding these processes is crucial for developing therapies to mitigate inflamm-aging and improve skin function in the elderly.