Skin as a Window to Endocrine Dysfunction: Dermatological and Metabolic Interactions in Polycystic Ovary Syndrome

This review highlights the dermatological manifestations of Polycystic Ovary Syndrome (PCOS) and their connection to endocrine dysfunction, emphasizing the importance of dermatologists in managing systemic risks. Key cutaneous markers such as hirsutism, acne, and acanthosis nigricans are indicative of hyperandrogenism and insulin resistance. The review underscores the effectiveness of a multidisciplinary treatment approach, combining hormonal therapies, metabolic interventions, and lifestyle changes, with a 5–10% weight loss significantly improving outcomes. Additionally, it explores emerging research on the "gut-skin axis" and adipokine profiling for phenotype-specific diagnosis, presenting new opportunities for understanding and managing PCOS.