Skin-Associated Cartilage Consists of Lipid-Filled Cells That Modify Hair Growth via BMP and WNT Signaling

The study identifies a unique type of skeletal cell called lipochondrocytes (LCs) in facial cartilages, which resemble adipocytes but have stable lipid vacuoles crucial for tissue morphology and biomechanics. LCs, found near hair follicles, engage in signaling that affects hair growth. In mice, ear hair follicles enter a prolonged rest phase due to high levels of BMP5 and WNT antagonist WIF1 expressed by LCs. By altering BMP and WNT signaling, researchers were able to stimulate hair cycle re-entry in these follicles. This research highlights the role of skin-associated cartilage in modulating hair growth through specific signaling pathways.