Common Skin Diseases and Metabolic Syndrome: A Proinflammatory Chemokine Perspective

This review examines the connection between chronic inflammatory skin diseases and metabolic syndrome, focusing on the role of pro-inflammatory chemokines like CCL5/RANTES and CXCL12/SDF-1a. These chemokines contribute to inflammation, a shared factor in both conditions, and are involved in various skin diseases such as psoriasis, atopic dermatitis, and alopecia areata. The review highlights the complex interactions between chemokines and inflammatory pathways, oxidative stress, and adipokine dysregulation, although the precise pathological links remain partially understood. It underscores the bidirectional relationship between obesity and psoriasis and the potential of integrated treatments targeting both skin inflammation and metabolic dysfunction. Chemokines like MCP-1 and GRO-α are suggested as potential biomarkers and therapeutic targets, with implications for improving patient outcomes in these interconnected conditions.