Dynamic Remodeling of Skin Microbiota During Healthy Homeostatic and Wound Repair Conditions

February 2026 in “ Frontiers in Microbiology ”

Hailv Ye, Aloysius Wong, Xiong Chen, Wenxuan Sun, Huacheng He, Xiaokun Li, Jiang Wu

skin microbiota wound healing inflammation tissue regeneration skin barrier microbiota-based therapies skin microbial homeostasis

TLDR Skin bacteria help heal wounds and restore healthy skin.

This review explores the dynamic changes in skin microbiota during the transition from healthy skin to wounded skin and back to a remodeled homeostatic state. It emphasizes the role of commensal microorganisms in the inflammatory, proliferative, and remodeling phases of wound healing, particularly in resolving inflammation, regenerating tissue, and restoring the skin barrier. The review also discusses potential microbiota-based therapies for wound management and identifies challenges and future research directions to support the long-term restoration of skin microbial homeostasis.

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