Molecular Changes in Skin Predict Predisposition to Breast Cancer

    February 2002 in “ Journal of Medical Genetics ”
    Veronica J. James
    TLDR Skin changes can indicate a risk for breast cancer.
    The study conducted by James et al. used synchrotron fibre diffraction to examine molecular changes in skin, specifically focusing on the ultrastructure of α-keratin in hair, to predict predisposition to breast cancer. The research involved skin samples from 192 individuals, including 172 controls and 12 patients with insulin-dependent diabetes mellitus (IDDM). The study found that while the only age-related change in dermal collagen was a variation in microfibrillar radius, the IDDM samples exhibited significantly lower microfibrillar radii. Additionally, fetal-like tissue was identified in the skin of healthy females with a family history of breast cancer, suggesting a potential molecular marker for breast cancer predisposition.
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