A Perspective on Small Molecules Targeting the Renin–Angiotensin–Aldosterone System and Their Utility in Cardiovascular Diseases: Exploring the Structural Insights for Rational Drug Discovery and Development

    January 2025 in “ RSC Medicinal Chemistry ”
    Nisha Bansal, Deepika Kathuria, Arockia Babu, Sonia Dhiman, Sorabh Lakhanpal, K. Nagendra Prasad, Roshan Kumar, Yogesh Kumar Tyagi, Bhupinder Kumar, Mahendra Pratap Singh, Abhay Gaidhane
    TLDR Targeting the RAAS with small molecules can improve cardiovascular disease treatments.
    The review discusses the critical role of the renin-angiotensin-aldosterone system (RAAS) in cardiovascular homeostasis and its disruption leading to cardiovascular diseases. It highlights the development of small molecules targeting RAAS components as a promising approach for innovative drug discovery. The article provides detailed insights into the pharmacodynamics, kinetics, and metabolism of these drugs, along with their limitations and mechanistic insights. It emphasizes the importance of integrating current therapies with new pharmacological strategies to enhance cardiovascular outcomes. Additionally, the review analyzes the chemical space parameters of RAAS modulators, aiding medicinal chemists in developing more selective and effective drug regimens.
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