Spread-Out Bragg Peak FLASH: Quantifying Normal Tissue Toxicity in a Murine Model

    July 2024 in “ Frontiers in Oncology ”
    Line Kristensen, P.R. Poulsen, Eleni Kanouta, Sky Rohrer, C. Ankjærgaard, C.E. Andersen, Jacob Johansen, Yuri Simeonov, Uli Weber, Cai Grau, Brita Singers Sørensen
    TLDR FLASH radiation reduces tissue damage more than conventional radiation.
    This study investigated the tissue-sparing effects of ultra-high dose rate (FLASH) radiation compared to conventional radiation within a Spread-out Bragg Peak (SOBP) in a murine model. Using female CDF1 mice, the study assessed acute and late radiation-induced damage, with doses ranging from 19.9-49.7 Gy for conventional and 30.4-65.9 Gy for FLASH. Results showed that FLASH radiation provided significant normal tissue protection, with a mean protection ratio of 1.40 for acute skin toxicity and 1.18 for fibrotic development. The findings confirm that FLASH radiation within the SOBP maintains its tissue-sparing benefits, offering a 40% reduction in acute skin damage and an 18% reduction in fibrotic development compared to conventional radiation.
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