Understanding Sonic Hedgehog (Shh) Expression and Its Distribution in Common House Gecko (Hemidactylus Platyurus) Tail Regeneration

The study on the common house gecko (Hemidactylus platyurus) reveals that the Sonic hedgehog (Shh) pathway plays a crucial role in tail regeneration. Conducted with 28 geckos, the research shows that Shh expression begins on day 1 post-autotomy, peaks at day 14, stabilizes until day 21, and decreases by day 30. There is a strong positive correlation between Shh expression and tail length from day 1 to day 14, and a strong negative correlation from day 21 to day 30. The findings emphasize Shh's importance in tissue homeostasis and the proliferation, migration, and differentiation of blastema cells during the regeneration process.