Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation

The document discussed the role of the morphogen Sonic Hedgehog (Shh) in maintaining the homeostasis and function of epithelial barrier tissues, specifically the skin and airway. It highlighted the importance of these barriers in protecting against environmental insults and allergens, and how their failure could lead to inflammatory disorders like atopic dermatitis and asthma. The study focused on the impact of Shh signalling on tissue repair, inflammation, and the development of atopic diseases in postnatal skin and lung tissues.