Immunohistochemical Assessment of SOX10 and Its Relation to the Immune Cellular Infiltrate in Alopecia Areata Follicles

August 2024 in “ Journal of the Egyptian Womenʼs Dermatologic Society ”

Sherif Awad, Amal T. Abdel‐Rahman, Manal Gabril, Keroles Nageh, Ahmed F. Rezk

SOX10 alopecia areata inflammatory infiltrates melanocytes autoimmunity hair follicles AA

TLDR SOX10 in hair follicles is linked to inflammation in alopecia areata.

The study investigated the expression of SOX10 in hair follicles of 16 patients with alopecia areata (AA) and its relation to inflammatory infiltrates. Results showed that SOX10 was expressed in 53 out of 81 examined AA follicles and had a significant positive relationship with the inflammatory infiltrate (P = 0.001). This suggests that melanocytes, marked by SOX10, may carry the antigenic epitope necessary to trigger organ-specific autoimmunity in AA, potentially explaining why only white hair follicles regrow in some AA cases.

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