Sox11 And Sox4 Drive The Reactivation Of An Embryonic Gene Program During Murine Wound Repair

    September 2019 in “ Nature Communications ”
    Qi Miao, Matthew C. Hill, Fengju Chen, Qianxing Mo, Amy T. Ku, Carlos Ramos, Elisabeth Sock, Véronique Lefebvre, Hoang Nguyen
    Image of study
    TLDR SOX11 and SOX4 help skin cells act like embryonic cells to heal wounds in mice.
    The study demonstrated that during wound repair in a mouse model, epidermal cells at the wound edge reverted to an embryonic-like state, significantly altering cytoskeletal and extracellular matrix components. SOX11 and SOX4 were identified as key regulators of this process, controlling genes related to epidermal development and cytoskeletal organization. Inducing SOX11 postnatally repressed epidermal differentiation, while deficiencies in SOX11 and SOX4 accelerated differentiation and impaired cell motility and re-epithelialization. The study highlighted fascin actin-bundling protein 1 (FSCN1) as a crucial target of SOX11 and SOX4, essential for cell migration, thus underscoring the importance of these factors in reactivating an embryonic gene program during wound repair.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results