The Value of Immunohistochemical Expression of SOX9 and CD34 in Alopecia Areata

July 2024 in “ Journal of Immunoassay and Immunochemistry ”

Heba A. S. Bazid, Alaa Marae, Bassant Farag, Rania Abdallah Abdallah

SOX9 CD34 alopecia areata hair follicle stem cells progenitor cells AA

TLDR Alopecia areata patients have lower SOX9 and CD34 levels, affecting hair growth.

This study investigated the expression of SOX9 and CD34 as markers of hair follicle stem cells and progenitor cells in 20 alopecia areata (AA) patients compared to 20 healthy controls. Results showed significantly lower levels of these markers in lesional samples from AA patients, with SOX9 levels negatively correlated with the severity of alopecia. Reduced SOX9 expression was also associated with recurrent attacks, suggesting a pathological impact on hair follicle stem cells and their ability to generate new hair. The study highlights the need for further research due to its small sample size.

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