Phenotypic, Transcriptomic, and Genomic Analyses Reveal the Spatiotemporal Patterns and Associated Genes of Coarse Hair Density in Goats

    January 2025 in “ 动物学研究 ”
    Jipan Zhang, Min Xiao, Jun Fang, Deli Huang, Yong-Ju Zhao, Zhao Yong-Ju, 重庆市草食动物科学重点实验室, 重庆 400715, 中国, 重庆市饲料与草食动物重点实验室, 重庆 400715, 中国, 重庆腾达牧业股份有限公司, 重庆 402360, 中国
    TLDR The gene GJA1 is important for regulating coarse hair density in goats.
    This study on the Dazu black goat provides insights into the genetic regulation of coarse hair density (CHD) by analyzing 905 skin images, 33 skin transcriptomes, 272 whole-genome sequences, and 182 downloaded transcriptomes. It reveals that hair shaft thickening and density decline are linked to trunk skin expansion. The research identifies 572 differentially expressed genes and 25 significant SNPs, with a focus on the gene <i>GJA1</i> on chromosome 9. Six genes, including <i>GJA1</i> and <i>GPRC5D</i>, are highlighted for their roles in skin and hair biology. These genes are highly expressed in hair follicles, particularly in follicular stem cells and dermal papilla cells, indicating their importance in folliculogenesis and structural maintenance. The study's findings, supported by cross-validation with public datasets, enhance understanding of hair density regulation in animals.
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