Spectrum and signals of medication-associated cognitive disorder: a comprehensive disproportionality analysis with cross-database validation

This study conducted a comprehensive disproportionality analysis using data from the FDA Adverse Event Reporting System and validated findings with international databases to identify significant signals of drug-related cognitive disorders across 41,775 reports. It found that 50 medications, including finasteride, showed notable signals for cognitive disorders, with 74% lacking relevant warnings on FDA labels. The analysis revealed that certain drugs were disproportionately reported in vulnerable groups, such as children and seniors. The study emphasizes the need for further research and potential updates to drug labels, while noting that the findings indicate statistical associations rather than causal links between the drugs and cognitive disorders.