A Regenerative Stem Cell-Derived Matrix Accelerates Functional Dermal Wound Repair in a Preclinical Diabetic Model

February 2026

Colette A. Abbey, Joshua Benton, Erin Goebel, Jocelyn Ma, Sebastian Lomeli, Indu Kancharla, Ivan Juarez, Akshaya Kannan, Christopher Story, Andrew Haskell, Hussain Alcassab, Kayla J. Bayless, Carl A. Gregory

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3 / 3 results

research Diabetes Mellitus Inhibits Hair Follicle Regeneration by Inducing Macrophage Reprogramming-Mediated Pyroptosis

September 2024 in “Journal of Inflammation Research”

Type 1 Diabetes prevents hair growth by causing cell death in hair follicles.

research Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice: A Mechanistic Systematic Review

10 citations , August 2022 in “International Journal of Molecular Sciences”

Leptin-deficient mice, used as a model for Type 2 Diabetes, have delayed wound healing due to impaired contraction and other dysfunctional cellular responses.

research Skin Wound Healing in Humans and Mice: Challenges in Translational Research

276 citations , December 2017 in “Journal of Dermatological Science”

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.