The Stem Cell Niche

    October 2008 in “ The Journal of Pathology ”
    MR Walker, KK Patel, TS Stappenbeck
    TLDR Stem cell niches are essential for tissue health and repair.
    The document reviewed the concept of the stem cell niche, emphasizing its critical role in regulating stem cells and their progenitors across various systems, including the skin, hair follicles, and neural environments. It described the niche as a microenvironment providing essential support and regulatory signals, influencing stem cell self-renewal and differentiation. The review highlighted specific signaling pathways, such as Wnt, JAK-STAT, BMP, and Notch, and the importance of niche components like integrins and growth factors (EGF, FGF-2) in maintaining tissue homeostasis and responding to injury. The complexity of mammalian niches, particularly in neural and epidermal systems, was noted, with proteins like Aspm and Numb playing crucial roles. The document concluded that further research was needed to fully understand these interactions and develop therapeutic targets for tissue-specific diseases.
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