Stem Cell-Based Tissue Engineering for the Treatment of Burn Wounds: A Systematic Review of Preclinical Studies

This systematic review examined 33 preclinical studies on stem cell-based tissue engineering for burn wound treatment, primarily using murine models and occasionally porcine models. The studies, published between 2009 and 2021, mostly involved thermal burns and applied stem cell treatments immediately after injury, with evaluation periods ranging from 7 to 90 days. Mesenchymal stromal cells (MSCs) were the most frequently used stem cell type, sourced from adipose tissue, bone marrow, or umbilical cord, often combined with various biomaterial scaffolds. The findings indicated that stem cell-based treatments showed promising results in enhancing skin wound repair in animal models, suggesting potential as an improved therapy for burn wounds.