Stem Cells and the Skin

November 2012 in “ Journal of cosmetic dermatology ”

Mark V. Dahl

stem cells epidermal stem cells hair follicles dermal stem cells hair papillae Wnt signaling pathway tissue repair regeneration hair

TLDR Stem cells can rejuvenate skin, restore hair, and aid in wound healing.

Stem cells, which can be embryonic or adult, have the potential to rejuvenate skin and restore hair by producing new skin cells through division and differentiation. Epidermal stem cells, located in niches such as the interfollicular epidermis and hair follicles, renew the epidermis, sebaceous glands, and hair follicles. Dermal stem cells, found in hair papillae and around pericytes, form various specialized dermal cells. The Wnt signaling pathway plays a crucial role in controlling stem cell fate. Stem cells may aid in wound healing, tissue repair, and the regeneration of aged skin, hair, nails, and mucous membranes.

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Research cited in this study

9 / 9 results

research Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches

179 citations , April 2012 in “Nature Communications”

Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.

research 25 Years of Epidermal Stem Cell Research

55 citations , March 2012 in “Journal of Investigative Dermatology”

Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.

research Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin

128 citations , October 2011 in “Development”

Activating a protein called β-catenin in adult skin can make it behave like young skin, potentially helping with skin aging and hair loss.

research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

260 citations , June 2011 in “Cell”

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

research Improved Hair Restoration Method for Burns Using Partial Longitudinal Follicular Unit Transplantation

20 citations , December 2010 in “Burns”

PL-FUT is an effective hair restoration method for burn victims with minimal scarring and high patient satisfaction.

research Epidermal Stem Cells: Practical Perspectives and Potential Uses

62 citations , April 2009 in “British Journal of Dermatology”

Epidermal stem cells could lead to new treatments for skin and hair disorders.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations , February 2009 in “Nature Reviews Molecular Cell Biology”

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

research Human Skin Stem Cells and the Aging Process

143 citations , September 2008 in “Experimental gerontology”

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

research More Than One Way to Skin

218 citations , April 2008 in “Genes & Development”

Skin stem cells help repair damage and maintain healthy skin.

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