Multiomics Global Landscape of Stemness-Related Gene Clusters in Adipose-Derived Mesenchymal Stem Cells

July 2020 in “ Stem Cell Research & Therapy ”

Guanming Lu, Yong-Xian Rong, Zhi-Jie Liang, Dong-Lin Hunag, Yanfei Ma, Zhizhai Luo, Fang-Xiao Wu, Xinheng Liu, Yu Liu, Steven Mo, Zhongquan Qi, Hongmian Li

adipose-derived mesenchymal stem cells stemness ITGAV MAD2L1 PCNA transcription factors lncRNAs KEGG pathways cell proliferation cell differentiation cell migration

TLDR Young donor, early passage stem cells have the highest stemness.

The study provided a comprehensive multiomics analysis of adipose-derived mesenchymal stem cells (AD-MSCs), focusing on stemness-related gene clusters. It found that stemness was highest in cells from young donors at early passages and decreased with cell passage and donor age. Key genes such as ITGAV, MAD2L1, and PCNA were more highly expressed in early-passage cells from young donors. The research identified 25 transcription factors and 16 lncRNAs regulating 21 KEGG pathways through 27 mRNAs, which could aid in selecting AD-MSCs with enhanced stemness for therapeutic applications. However, the study was limited by its small sample size, involving only two female donors, and required further experimental validation.

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