Effects of Steroid Hormones on Developing Mouse Skin In Vitro

    August 1975 in “ Journal of Endocrinology ”
    Amreek Singh, Margaret H. Hardy
    TLDR Cortisol and corticosterone thin mouse skin and regress hair follicles, while testosterone promotes skin and hair development.
    In this study, pieces of skin from 13.5- to 15-day-old fetal mice were cultured in vitro with and without hormonal steroids. Cortisol at 7.5 μg/ml caused thinning of the non-cornified epidermis and flattening of the stratum granulosum after 3 days, with further thinning and hair follicle regression observed by 6 days, continuing up to 12 days. Corticosterone at 5 μg/ml also led to epidermal thinning and follicle regression after 6 days. In contrast, testosterone at 100 μg/ml resulted in good differentiation of the epidermis and hair follicles, with the non-cornified epidermal layers being similar to controls at 3 days but less than half as thick at 6 days. Hair follicles differentiated rapidly, and sebaceous gland anlagen developed by 6 days, with some sebaceous cell differentiation observed at 9 days.
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