Natural Sweetener Stevioside-Based Dissolving Microneedles Solubilize Minoxidil for the Treatment of Androgenic Alopecia

January 2026 in “ Advanced Healthcare Materials ”

Junying Zhang, Tianyu Shao, Hailiang Li, Luying Zhu, Lamyaa Albakr, Nial Wheate, Lifeng Kang, Chungyong Wu

stevioside dissolving microneedles minoxidil androgenic alopecia nanomicelles microneedle patches Rogaine

TLDR Stevioside-based microneedles improve minoxidil delivery for effective hair growth treatment.

The study explores the use of stevioside-based dissolving microneedles to enhance the solubility and delivery of minoxidil for treating androgenic alopecia. Stevioside, a natural sweetener, forms nanomicelles that encapsulate minoxidil, improving its solubility and effectiveness. The microneedle patches are applied to the skin, and the study highlights their therapeutic efficacy in promoting hair growth, as well as their safety and biocompatibility. The research suggests that this innovative approach could offer a promising alternative for individuals suffering from hair loss due to androgenic alopecia.

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Toothpaste containing α-tocopherol acetate, l-menthol, and stevioside can promote hair growth in mice.

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A mix of tocopherol acetate and L-menthol helps grow hair better than using them separately or using minoxidil.

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A Thallium-Based Screening Procedure to Identify Molecules That Modulate the Activity of Ca2+-Activated Monovalent Cation-Selective Channels

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The conclusion is that a new test was created to find substances that affect specific ion channels, and it works well for drug discovery.