A Prospective Observational Study for Assessment of Chemotherapy-Induced Adverse Drug Reactions in Cancer Patients

April 2025 in “ Journal of Pharma Insights and Research. ”

Ravi Prakash Degala, Govinda Rao Kamala, Nagalaxmi Pinnamraju, K.A. Sunitha, Ramya Sri Bura, Sujatha Gorle

alopecia chemotherapy-induced alopecia skin changes dermatological systems

TLDR Females had more chemotherapy side effects than males, with many being preventable.

The study assessed chemotherapy-induced adverse drug reactions (ADRs) in 135 cancer patients over six months, revealing that females experienced more ADRs than males, with breast cancer being the most common malignancy. Alopecia, nausea, vomiting, and skin changes were frequent ADRs, affecting mainly gastrointestinal and dermatological systems. Using Naranjo's scale, 76% of ADRs were deemed probable, and Hartwig's scale showed 58.03% were mild. Schumock and Thornton criteria indicated 62% of reactions were preventable. No significant link was found between ADR severity and age or gender. The study highlights the need for better pharmacovigilance and personalized treatment to reduce ADRs.

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