Abrocitinib, a JAK1 inhibitor approved for atopic dermatitis, has shown promise in treating alopecia universalis (AU), particularly in patients with co-morbid atopic dermatitis. This case report details a patient with AU following a drug reaction with eosinophilia and systemic symptoms (DRESS) who experienced significant improvement with abrocitinib at doses of 100 and 200 mg daily. The study also reviewed alopecia cases post-DRESS and discussed the autoimmune mechanisms of alopecia areata, suggesting that JAK inhibitors like abrocitinib may work by affecting cytokines such as IFN-γ and IL-15. This indicates that abrocitinib could be an effective treatment for stubborn cases of AU.
2 citations
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January 2023 in “Journal of Dermatology” Some types of hair loss can continue for a long time after recovering from a severe drug reaction known as DRESS.
2 citations
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August 2022 in “Federal Practitioner” A severe medication reaction required long treatment and led to hair loss and thyroid issues.
11 citations
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February 2022 in “JAAD case reports” Abrocitinib, a JAK inhibitor, may help treat atopic dermatitis and alopecia universalis together.
290 citations
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August 2021 in “Clinical Reviews in Allergy & Immunology” JAK inhibitors show promise for treating alopecia areata, but more research is needed.
238 citations
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November 2016 in “Journal of The American Academy of Dermatology” Tofacitinib is effective and safe for severe hair loss, but full regrowth is less likely after 10 years of hair loss.
6 citations
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March 2019 in “JAAD case reports” A new mix of anthralin and calcipotriene might help treat severe hair loss.
148 citations
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December 2018 in “Journal of autoimmunity” Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.
4 citations
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November 2018 in “JAAD case reports” Alopecia areata can sometimes appear as a straight line of hair loss instead of round patches.
May 2018 in “Journal of cosmetology & trichology” Combining platelet-rich plasma therapy with prostaglandin-F eye drops can significantly regrow hair in alopecia universalis.
