Distinct Use of Super-Enhancer Elements Controls Cell Type-Specific CD25 Transcription and Function

    November 2023 in “ Science Immunology ”
    Rosanne Spolski, Peng Li, Vivek Chandra, Boyoung Shin, Shubham Goel, Keiko Sakamoto, Chengyu Liu, Jangsuk Oh, Min Ren, Yutaka Enomoto, Erin E. West, Stephen M. Christensen, Chi‐Keung Wan, Meili Ge, Jian-Xin Lin, Bingyu Yan, Majid Kazemian, Zu‐Xi Yu, Keisuke Nagao, Pandurangan Vijayanand, Ellen V. Rothenberg, Warren J. Leonard
    TLDR Super-enhancers control CD25 expression in specific cell types, affecting immune function.
    The study investigates the regulation and function of CD25 expression through super-enhancer elements in mice. It reveals that distinct super-enhancer regions control constitutive and inducible CD25 expression in a cell type-specific manner. Deleting the upstream super-enhancer region affects constitutive CD25 expression on DN2/DN3 thymocytes and regulatory T cells, leading to autoimmune alopecia. In contrast, deleting an intronic region reduces IL-2-induced CD25 expression on peripheral T and NK cells. The study highlights the role of the mediator-1 coactivator and chromatin interactions in these processes, offering insights into manipulating CD25 expression in specific cell types.
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