Synthetically Programmed Antioxidant Delivery by a Domesticated Skin Commensal

    February 2025 in “ Cell Systems ”
    Guillermo Nevot, Javier Santos‐Moreno, Nil Campamà Sanz, Lorena Toloza, Cristóbal Parra-Cid, Patrick A.M. Jansen, Içvara Barbier, Rodrigo Ledesma‐Amaro, Ellen H. van den Bogaard, Marc Güell
    Researchers have developed a genetic toolbox to engineer Cutibacterium acnes, a bacterium located in hair follicles, for dermal biotechnological applications. This includes tools for gene expression, biocontainment, markerless genetic engineering, and transcriptional regulation. As a proof of concept, they created an antioxidant-secreting strain that can reduce oxidative stress in a UV stress model, demonstrating the potential of using bacteria as a dynamic delivery system for skin treatments.
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