Table 1_A decade of hair-loss clinical trials: a registry-based analysis of studies registered on ClinicalTrials.gov.docx

The analysis of 514 hair-loss clinical trials registered on ClinicalTrials.gov from 2015 to 2025 shows a significant increase in registrations after 2020, with a focus on androgenetic alopecia and alopecia areata. Most trials were concentrated in North America and involved pharmacologic therapies. The study highlights the need for standardized outcomes, broader population representation, and better alignment between research investment and clinical needs. Despite the growth in trial volume, there are methodological inconsistencies and underrepresentation of conditions like telogen effluvium and cicatricial alopecias. The findings emphasize the importance of registry-based meta-research for understanding evidence generation in hair-loss disorders.