Tannic Acid and Silicate-Functionalized Polyvinyl Alcohol–Hyaluronic Acid Hydrogel for Infected Diabetic Wound Healing

The study presents a novel injectable polyvinyl alcohol-hyaluronic acid-based composite hydrogel, PTKH, functionalized with tannic acid and silicate, designed to aid in the healing of chronic diabetic wounds. The hydrogel forms an adhesive and protective dressing upon injection, with adjustable properties through TA and silicate content. It effectively reduces reactive oxygen species, combats infection, and promotes a favorable environment for wound healing. Animal studies showed that PTKH significantly enhances angiogenesis and epithelization while reducing inflammation and infection risks, indicating its potential as a promising treatment for chronic diabetic wounds.