Targeting the Complexity of In Vitro Skin Models: A Review of Cutting-Edge Developments

August 2024 in “ Journal of Investigative Dermatology ”

Cristina Quílez, Luís B. Bebiano, Eleri Jones, Uroš Maver, Luca D. Meesters, Piotr Parzymies, Emma Petiot, Gijs Rikken, Ignacio Risueño, Hamza Zaidi, Tanja Zidarič, Sander Bekeschus, Ellen H. van den Bogaard, Matthew Caley, Helen Colley, Nuria Gago‐López, Sophia Letsiou, Christophe A. Marquette, Tina Maver, Rúben F. Pereira, Desmond J. Tobin, Diego Velasco

TLDR In vitro skin models are improving but still need more innovation to fully replicate human skin.

The review discusses advancements in in vitro skin models, emphasizing their complexity and potential applications in research and therapy development. It highlights innovative techniques like 3D bioprinting and organ-on-a-chip technology, which improve physiological relevance and allow for accurate drug testing, disease modeling, and exploration of regenerative therapies. Despite progress, challenges remain in replicating the full complexity of human skin, including proper epidermal stratification and the incorporation of hair follicles and sebaceous glands. The review underscores the need for further innovation and standardized reporting to enhance model quality and bridge the gap between academic and industrial applications.

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