Telocytes: Current Methods of Research, Challenges and Future Perspectives

    March 2024 in “ Cell and Tissue Research ”
    Bruno D. A. Sanches, Francisco Breno Silva Teófilo, Mathieu Brunet, Victor M. Villapún, Kenny Man, Lara Caetano Rocha, Jurandyr Pimentel Neto, Marta R. Matsumoto, Juliana S. Maldarine, Adriano Polican Ciena, Sophie C. Cox, Hernandes F. Carvalho
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    TLDR Telocytes have potential in therapy and tissue regeneration, but challenges in identification and cultivation remain.
    Telocytes (TCs) are specialized stromal cells with significant roles in organ physiology and potential therapeutic applications. Current research focuses on identifying TCs using electron microscopy and immunostaining, though challenges remain due to phenotypic variations and the absence of definitive markers. TCs are involved in immune activation, oxidative stress reduction, and tissue regeneration, with extracellular vesicles from TCs showing promise in promoting cell survival. Future research aims to establish commercial TC lines, precise genetic markers, and explore TCs' therapeutic potential in diseases like fibrosis and cancer. Despite advancements, difficulties in culturing and isolating TCs persist, necessitating further study.
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