Effects of Chronic Inhibition of Testosterone Metabolism on Cardiac Remodeling After Ischemia/Reperfusion-Induced Myocardial Damage in Gonadectomized Rats

    May 2019 in “ Biology open ”
    Octavio Maldonado, ADRIANO FERRARETO RAMOS, Mario Guapillo, José María Rivera, Ícela Palma, Iván Rubio-Gayosso, Israel Ramírez-Sánchez, Nayelli Nájera, Guillermo Ceballos, Enrique Méndez-Bolaina
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    TLDR Testosterone reduces heart damage and inflammation after injury.
    The study evaluated the effects of testosterone and its metabolic inhibition on myocardial remodeling in gonadectomized rats after ischemia/reperfusion injury. Testosterone administration reduced myocardial damage, inflammation, and MMP-3 and 13 expressions. Finasteride further decreased scar tissue and inflammation, while 4-hydroxyandrostenedione increased these parameters. The findings suggested that testosterone's effects were not direct, as inhibiting both aromatase and 5α-reductase did not significantly alter myocardial injury.
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