Effect of Testosterone and Its Antagonists on Knee Range of Motion Through RXFP1 and RXFP2 Regulation in Rat Model

April 2014 in “ The FASEB Journal ”

Firouzeh Dehghan, Sekaran Muniandy, Ashril Yusof, Naguib Salleh

testosterone flutamide finasteride RXFP1 RXFP2 Propecia

TLDR Testosterone reduces knee movement, while flutamide and finasteride increase it.

The study investigated the effects of testosterone and its antagonists, flutamide and finasteride, on knee joint range of motion (ROM) in 42 ovariectomized female Wistar Kyoto rats. Testosterone was found to decrease knee ROM, while the antagonists increased it. Both flutamide and finasteride independently blocked testosterone's effects and increased the expression of RXFP1 and RXFP2 receptors in the patellar tendon and collateral ligament. The findings suggested that testosterone acted as a primary mediator in reducing knee ROM through RXFP1 and RXFP2 receptors, while the antagonists inhibited this effect by altering receptor expression.

View this study on faseb.onlinelibrary.wiley.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community What Works to Restore Hairloss for Cis-Males? Not Much

in Treatment 19 upvotes 5 years ago

Hair regrowth treatments for cis-males include Minoxidil, Finasteride, and RU58841. Estrogen and testosterone blockers can help restore hair loss but may not suit everyone.

community pyrilutamide GB update please? Anything no matter how big or small

in Update 32 upvotes 3 years ago

The effects of Finasteride on hair loss and its side-effects, such as aching balls. The user has been taking it for two years with no changes to the symptom.

community Are these all the anti androgen products?

in Treatment 6 upvotes 2 years ago

The conversation lists hair loss treatments including finasteride, dutasteride, RU58841, pyrilutamide, breezula, and fluridil, and suggests ketoconazole as another option. Some users warn against using certain treatments like cyproterone acetate, bicalutamide, and spironolactone due to their strong anti-androgen effects and potential impact on masculinity.

community Serious question, is there nothing that can be done if Dutasteride doesn’t help to stop my hair loss?

in Finasteride/Dutasteride 61 upvotes 3 years ago

A 25 year old male who has been using finasteride and dutasteride for two years to treat his hair loss, with no success. Other treatments such as oral minoxidil, topical anti-androgens, RU58841, latanoprost, topical estrogen, CB 03 01, microneedling, keto 2% shampoo, vitamin D, Omega 3, B vitamins and probiotics were discussed.

community Sugar and hairloss

in Research/Science 11 upvotes 4 years ago

Cutting sugar may not significantly impact hair loss, as DHT and androgen receptors are the main issues. Effective treatments include finasteride, dutasteride, RU58841, and minoxidil, often combined with microneedling.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 674 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

Related Research

1 / 1 results

research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity

37 citations , November 1995 in “Journal of Investigative Dermatology”

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.