The Functions and Mechanisms of TGF-β3 Signaling in Controlling the Fate Determinations of Various Types of Stem Cells

February 2026 in “ Journal of Cellular Physiology ”

Linzhi Kuang, J.-W. Xiang, ZUPING HE

TGF-β3 hair-follicle stem cells Smad signalling pathways non-classical signalling pathways cell surface receptors

TLDR TGF-β3 controls stem cell growth and development, varying by cell type and conditions.

This review explores the role of TGF-β3 in determining the fate of various stem cells, including neural, haematopoietic, odontogenic, hair-follicle, adipose-derived, and mesenchymal stem cells. TGF-β3 influences stem cell proliferation, differentiation, and cell death through both classical Smad and non-classical signalling pathways, initiated by binding to specific cell surface receptors. The effects of TGF-β3 are highly dependent on the cell type and conditions, involving factors like concentration and interactions with other genes or non-coding RNAs. The review provides detailed insights into the molecular mechanisms of TGF-β3, offering a foundation for future therapeutic interventions in human diseases.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

research Exosomes Derived Stem Cells as a Modern Therapeutic Approach for Skin Rejuvenation and Hair Regrowth

June 2024 in “Regenerative Therapy”

Exosomes from stem cells may help rejuvenate skin and regrow hair, but more research is needed.

research Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

12 citations , October 2021 in “Cells”

Targeting a protein that blocks hair growth with microRNAs could lead to new hair loss treatments, but more research is needed.

research Mesenchymal Stem Cells for Regenerative Medicine

1036 citations , August 2019 in “Cells”

Mesenchymal stem cells can help repair body tissues with low risk of rejection.

research Stem Cell Therapy for Burns: The Story So Far

August 2021

Stem cell therapy shows promise for better burn healing but needs more research and standardization.

research Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing

5 citations , April 2022 in “Frontiers in Medicine”

Hair and skin healing involve complex cell interactions controlled by specific molecules and pathways, and hair follicle cells can help repair skin wounds.

The Functions and Mechanisms of TGF-β3 Signaling in Controlling the Fate Determinations of Various Types of Stem Cells

Related Community Posts Join

community Comprehensive Microneedling Guide

community Does Finasteride Sustain Minoxidil-grown Hairs?

community Why is nobody studying the difference between donor and balding hair?

community If Minoxidil Beards are permanent, why should Finasteride be unable to keep Minoxidil Gains on the scalp?

community dunno if it's growing anything but it's making my scalp red