Effects of TGFBR1 on Proliferation of Dermal Papilla Cells in Fine-Wool Sheep

The study explores the role of TGFBR1 in regulating dermal papilla cell (DPC) proliferation in fine-wool sheep, identifying it as a key negative regulator of wool fiber diameter. Using six 14-month-old Alpine Merino ewes, researchers employed gene knockdown and overexpression techniques, finding that TGFBR1 suppresses DPC proliferation by modulating signaling pathways like Wnt/β-catenin, BMP, and Notch. Overexpression of TGFBR1 inhibited DPC proliferation, while knockdown enhanced it, affecting genes associated with hair follicle development. These findings provide insights into the molecular mechanisms of hair follicle development and suggest potential targets for improving wool traits through molecular breeding strategies.