The Telomerase Reverse Transcriptase (TERT) Gene Molecular Characterization in Sheep and the Association of Its Variation with Wool Traits

This study examined the Telomerase Reverse Transcriptase (TERT) gene in 315 Gansu alpine fine wool sheep to explore its impact on wool traits. Researchers identified six single nucleotide polymorphisms (SNPs) in the TERT gene, with two non-synonymous SNPs linked to mean wool staple strength (MSS). Notably, sheep with the CC genotype at SNP1 and GG genotype at SNP2 exhibited higher MSS, indicating potential for improved textile manufacturing. TERT mRNA expression was particularly strong in the dermal papilla, suggesting a role in hair follicle regeneration and wool fiber growth. While these findings highlight TERT as a candidate gene for wool strength, further studies across different sheep populations are necessary to validate these results.