Therapeutic applications of electrospun nanofibers impregnated with various biological macromolecules for effective wound healing strategy – A review

The review discussed the challenges of non-healing infected wounds, particularly those related to chronic conditions like diabetes, and the limitations of current commercial wound therapies. It highlighted the potential of nanomaterial-based drug delivery systems, specifically electrospun nanofibers impregnated with biological macromolecules, in enhancing wound healing through improved cell proliferation and bioactive molecule delivery. While these nanofibers showed promise in skin re-epithelialization, the review noted a lack of updated research on their drug-targeted delivery, anti-scarring properties, and tissue regeneration capabilities. The review aimed to explore these aspects and the advancements in nanomaterials for tissue engineering, suggesting that these innovations could lead to more effective wound scaffolds for drug delivery.